Opportunity Information: Apply for 7200AA24RFA00001
Ending Neglected Diseases through Operational Research (ENDOR) is a USAID-funded global health opportunity designed to strengthen how neglected tropical disease (NTD) programs solve real implementation problems in endemic countries. USAID plans to make one award under a five-year cooperative agreement (meaning USAID will remain actively involved in guiding and collaborating on the work). The call is issued under NOFO number 7200AA24RFA00001, with questions due by November 6, 2023 at 1:00 PM Washington, DC time, and applications due by December 8, 2023 at 1:00 PM Washington, DC time. The opportunity is listed as discretionary funding in the health category (CFDA 98.001), with eligibility described as unrestricted (open to any type of entity, including consortia, subject to any additional eligibility language in the full notice). USAID expects to make a single award with a ceiling of up to $45,000,000.
The core rationale for ENDOR comes from gaps identified in the WHO 2030 NTD Roadmap Gap Assessment and reinforced through discussions in the broader NTD community, including the WHO NTD Global Partners Meeting. These gaps include weaknesses in disease-specific strategies for mapping and understanding where transmission persists, challenges in monitoring and evaluation systems that can reliably show progress and inform course corrections, limited availability of accurate diagnostics that are practical for field settings, and the need for more sustainable public health and surveillance systems that countries can maintain over time. USAID notes that these issues are routinely encountered by endemic-country programs and implementing partners, including in USAID flagship NTD efforts such as Act East (led by RTI) and Act West (led by FHI360).
A major theme in the ENDOR design is the growing complexity of NTD work as more countries move toward control and elimination. As programs succeed and community-wide mass drug administration winds down, countries face a different set of operational questions: how to prevent resurgence, how to run periodic surveillance that is both affordable and sensitive enough to detect recrudescence, and how to maintain essential NTD services after elimination or control thresholds are reached. ENDOR is positioned as a way to generate practical, program-ready evidence to guide these post-elimination and sustaining-progress strategies, not just publish research findings.
The opportunity is organized around four high-level focus areas. First, ENDOR aims to foster and convene a network of local and international investigators, with explicit attention to including young and mid-career researchers, and to make the process of identifying and prioritizing operational research needs more diverse and equitable. Second, it will define and carry out coordinated research initiatives that USAID and its NTD implementing partners prioritize, specifically targeting barriers and evidence gaps highlighted by the WHO roadmap and the wider NTD community. Third, it will improve the speed and quality of operational research by issuing subawards directly to local and endemic-country institutions, enabling quicker responses to persistent and emerging implementation challenges and translating results into concrete programmatic solutions that endemic countries can apply. Fourth, ENDOR will work collaboratively with the broader NTD donor community to help ensure research support is equitable and aligned with real project needs, reducing duplication and improving coordination across funders.
In practical terms, ENDOR is less about funding stand-alone academic studies and more about building a functioning operational research engine that connects country programs, implementers, and researchers to solve immediate, field-driven problems. It emphasizes strengthening local leadership and institutional capacity through direct subawards, improving the usefulness and turnaround time of evidence, and ensuring research results are converted into changes in guidelines, tools, and implementation approaches that help countries reach and sustain NTD elimination goals through 2030 and beyond.Apply for 7200AA24RFA00001
- The Agency for International Development in the health sector is offering a public funding opportunity titled "Ending Neglected Diseases through Operational Research (ENDOR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
- This funding opportunity was created on Oct 26, 2023.
- Applicants must submit their applications by Dec 08, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $45,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: Ending Neglected Diseases through Operational Research (ENDOR)
What is the ENDOR opportunity?
Ending Neglected Diseases through Operational Research (ENDOR) is a USAID-funded global health opportunity focused on strengthening how neglected tropical disease (NTD) programs solve real, on-the-ground implementation problems in endemic countries through operational research.
What type of award is USAID planning to make?
USAID plans to make one award under a five-year cooperative agreement. A cooperative agreement indicates that USAID will remain actively involved in guiding and collaborating on the work.
How many awards does USAID expect to make?
USAID expects to make a single award under this opportunity.
What is the maximum funding amount available?
USAID expects the award to have a ceiling of up to $45,000,000.
What is the funding category and assistance listing information?
The opportunity is listed as discretionary funding in the health category, with CFDA listed as 98.001.
What is the NOFO number for this opportunity?
The Notice of Funding Opportunity (NOFO) number is 7200AA24RFA00001.
When are questions due?
Questions are due by November 6, 2023 at 1:00 PM Washington, DC time.
When are applications due?
Applications are due by December 8, 2023 at 1:00 PM Washington, DC time.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to any type of entity, including consortia, subject to any additional eligibility language in the full notice.
What problem is ENDOR intended to address?
ENDOR is intended to address persistent gaps that affect how NTD programs operate and make decisions in endemic countries, including weaknesses in disease-specific strategies for mapping and understanding where transmission persists, challenges with monitoring and evaluation systems that reliably show progress and inform course corrections, limited availability of accurate diagnostics suitable for field settings, and the need for more sustainable public health and surveillance systems that countries can maintain over time.
What informed the design and rationale for ENDOR?
The core rationale draws from gaps identified in the WHO 2030 NTD Roadmap Gap Assessment and was reinforced through discussions in the broader NTD community, including the WHO NTD Global Partners Meeting.
How does ENDOR relate to USAID's existing NTD efforts?
USAID notes that the kinds of operational issues ENDOR targets are routinely encountered by endemic-country programs and implementing partners, including within USAID flagship NTD efforts such as Act East (led by RTI) and Act West (led by FHI360).
Why is operational research emphasized, especially as countries make progress toward elimination?
ENDOR highlights that NTD work becomes more complex as more countries move toward control and elimination. As community-wide mass drug administration winds down, programs face operational questions such as how to prevent resurgence, how to run periodic surveillance that is affordable yet sensitive enough to detect recrudescence, and how to maintain essential NTD services after elimination or control thresholds are reached.
Is ENDOR intended to fund stand-alone academic research?
ENDOR is positioned as less about funding stand-alone academic studies and more about building a functioning operational research engine that connects country programs, implementers, and researchers to solve immediate, field-driven problems, with an emphasis on converting results into practical program changes.
What does ENDOR mean by producing "program-ready" evidence?
ENDOR emphasizes generating practical evidence that can guide implementation strategies, particularly for post-elimination and sustaining-progress contexts. The intent is not only to publish findings, but to translate results into concrete programmatic solutions that endemic countries can apply.
What are the main focus areas of ENDOR?
ENDOR is organized around four high-level focus areas: (1) fostering and convening a network of local and international investigators with attention to including young and mid-career researchers and making prioritization more diverse and equitable; (2) defining and implementing coordinated research initiatives prioritized by USAID and its NTD implementing partners and targeted to barriers and evidence gaps identified by the WHO roadmap and the wider NTD community; (3) improving the speed and quality of operational research through issuing subawards directly to local and endemic-country institutions and translating results into programmatic solutions; and (4) collaborating with the broader NTD donor community to support equitable, aligned research and reduce duplication across funders.
What role do local and endemic-country institutions play in ENDOR?
ENDOR emphasizes strengthening local leadership and institutional capacity, including by issuing subawards directly to local and endemic-country institutions to enable quicker responses to persistent and emerging implementation challenges.
How does ENDOR aim to improve the speed and quality of operational research?
It plans to do this in part by issuing subawards directly to local and endemic-country institutions, which is intended to speed up responses to implementation challenges and improve the relevance of research to country needs.
How does ENDOR approach equity and inclusion within research networks?
ENDOR explicitly highlights inclusion of young and mid-career researchers and seeks to make the process of identifying and prioritizing operational research needs more diverse and equitable.
How will ENDOR coordinate with other donors and the wider NTD community?
ENDOR will work collaboratively with the broader NTD donor community to help ensure research support is equitable and aligned with real project needs, with an emphasis on reducing duplication and improving coordination across funders.
What kinds of operational challenges are in scope for ENDOR?
Based on the described gaps and themes, ENDOR is intended to address issues such as mapping and understanding persistent transmission, strengthening monitoring and evaluation systems, improving access to accurate field-practical diagnostics, designing sustainable surveillance systems, preventing resurgence after mass drug administration scales down, detecting recrudescence through affordable and sensitive surveillance, and maintaining essential NTD services after control or elimination milestones are reached.
What is the intended time horizon for ENDOR's impact?
ENDOR is positioned to support countries in reaching and sustaining NTD elimination goals through 2030 and beyond, including strategies relevant to post-elimination and sustaining-progress phases.
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