Opportunity Information: Apply for PAR 18 679
The NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required) is a National Institutes of Health (NIH) grant program run by the National Institute of Allergy and Infectious Diseases (NIAID) aimed at strengthening the pipeline of independent physician-scientists. Its central goal is to help outstanding postdoctoral researchers who hold a clinical doctorate move more quickly and smoothly from a mentored postdoctoral research setting into an independent, tenure-track (or equivalent) faculty position. By backing that transition with dedicated research support, NIAID is trying to address a long-standing national shortage in the physician-scientist workforce and ensure more clinicians can build sustainable, competitive research careers in biomedical fields, particularly those aligned with NIAID's mission areas.
The structure of the award is the classic NIH "Pathway to Independence" model with two linked phases. The first phase (K99) supports the applicant while they are still in a mentored postdoctoral position, allowing them to deepen their research expertise, produce key publications, and complete targeted career development activities that prepare them for independence. The second phase (R00) is the independent phase that begins after the awardee secures an independent, tenure-track or equivalent faculty appointment. At that point, the funding shifts to support the awardee in launching and establishing their own research program, helping them generate the data, credibility, and momentum typically needed to compete successfully for major independent NIH grants later on. As the title indicates, this specific funding opportunity requires that the proposed research involve a clinical trial, meaning the project is expected to include prospective human research designed to evaluate the effects of an intervention or related clinical outcomes in a structured way, consistent with NIH's definition of a clinical trial.
Eligibility for applying spans a wide range of organization types that commonly participate in NIH funding, reflecting the broad ecosystem in which biomedical research happens. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city or township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. Tribal entities are also included, such as federally recognized Native American tribal governments and other Native American tribal organizations. The announcement also explicitly highlights additional eligible applicant categories that NIH often emphasizes for inclusivity and reach, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, the opportunity draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply either. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement. In practical terms, that usually means a U.S.-based applicant organization can include certain well-justified elements of the work that take place outside the U.S., as long as they are structured and documented as a foreign component under NIH rules and are scientifically necessary for the project.
From the administrative details provided, the opportunity is a discretionary NIH grant in the health funding activity category, associated with CFDA number 93.855, and is identified by funding opportunity number PAR 18 679. The record shows an original closing date of 2020-05-07 and a creation date of 2018-02-23. No award ceiling or expected number of awards is specified in the supplied text, which is not unusual in NIH listings where budgets and award counts may depend on annual appropriations, program priorities, and the number of meritorious applications in a given cycle. Overall, the program is designed to identify high-potential clinician-researchers early, support them through a critical career transition point, and position them to become stable, independent investigators conducting clinically relevant research, including clinical trials, within NIAID-relevant biomedical areas.Apply for PAR 18 679
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2018-02-23.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)
What is the NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)?
It is an NIH grant program run by the National Institute of Allergy and Infectious Diseases (NIAID) designed to strengthen the pipeline of independent physician-scientists. It supports outstanding postdoctoral researchers who hold a clinical doctorate as they transition from a mentored postdoctoral research environment into an independent, tenure-track (or equivalent) faculty position. This specific opportunity requires that the proposed research involve a clinical trial.
What is the main goal of this award?
The central goal is to help clinician-researchers move more quickly and smoothly from mentored postdoctoral training into independent faculty roles by providing dedicated research support across that transition. NIAID is using this mechanism to address the national shortage of physician-scientists and to help clinicians build sustainable, competitive biomedical research careers aligned with NIAID mission areas.
What does "Pathway to Independence" mean in this context?
"Pathway to Independence" refers to the linked two-phase structure that supports an applicant first during mentored postdoctoral training and then during the early period of independence as a faculty member, with the intent of launching a self-sustaining research program that can later compete for major independent NIH grants.
How is the award structured?
The award has two linked phases: a mentored K99 phase and an independent R00 phase. The K99 phase supports the awardee while they remain in a mentored postdoctoral position. The R00 phase begins after the awardee secures an independent, tenure-track or equivalent faculty appointment, at which point funding supports the launch of the awardee's independent research program.
What is the purpose of the K99 (mentored) phase?
The K99 phase supports the applicant in a mentored postdoctoral research setting to deepen research expertise, produce key publications, and complete targeted career development activities that prepare them for independence.
When does the R00 (independent) phase start?
The R00 phase starts after the awardee secures an independent, tenure-track or equivalent faculty appointment. At that point, the award shifts to support the awardee in establishing and running their own research program.
What does the R00 phase funding support?
The R00 phase supports the awardee as they launch and establish an independent research program, including generating data and building momentum typically needed to compete successfully for major independent NIH grants later on.
Is a clinical trial required for this opportunity?
Yes. As indicated by the title (K99/R00 Clinical Trial Required), the proposed research is expected to involve a clinical trial.
What does NIH mean by a "clinical trial" for this award?
Based on the description provided, the project is expected to include prospective human research designed to evaluate the effects of an intervention or related clinical outcomes in a structured way, consistent with NIH's definition of a clinical trial.
Who is this award intended for?
It is intended for outstanding postdoctoral researchers who hold a clinical doctorate and are aiming to become independent, tenure-track (or equivalent) faculty investigators. The emphasis is on supporting physician-scientists at a critical career transition point.
What kinds of organizations are eligible to apply?
Eligible applicants include a broad range of U.S. organization types commonly involved in NIH funding, including public and private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and various government entities (state, county, city or township, and special districts), as well as independent school districts and public housing authorities/Indian housing authorities.
Are tribal entities eligible to apply?
Yes. Eligible tribal entities include federally recognized Native American tribal governments and other Native American tribal organizations.
Does the opportunity highlight any additional eligible applicant categories?
Yes. The announcement explicitly highlights several categories often emphasized by NIH for inclusivity and reach, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Can a non-U.S. (foreign) organization apply?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply for this opportunity.
Can a U.S. organization apply if part of the project will be run outside the United States?
Non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement. This generally means a U.S.-based applicant organization may include well-justified elements of the work that occur outside the U.S. if they are scientifically necessary and properly structured and documented as a foreign component under NIH rules.
What is the funding activity category for this opportunity?
The opportunity is described as a discretionary NIH grant in the health funding activity category.
What is the CFDA number associated with this opportunity?
The CFDA number associated with this opportunity is 93.855.
What is the funding opportunity number?
The funding opportunity number provided is PAR 18 679.
What dates are listed for this opportunity?
The record lists a creation date of 2018-02-23 and an original closing date of 2020-05-07.
Is there an award ceiling or a stated expected number of awards?
No award ceiling or expected number of awards is specified in the provided information. The text notes this is not unusual for NIH listings where budgets and award counts can depend on annual appropriations, program priorities, and the number of meritorious applications in a given cycle.
How does this program relate to NIAID's mission?
The program is intended to support clinically relevant biomedical research careers, particularly in areas aligned with NIAID mission areas, while helping address the physician-scientist workforce shortage.
What is the broader workforce issue this program is trying to address?
NIAID is aiming to address a long-standing national shortage in the physician-scientist workforce by supporting high-potential clinicians through the transition to independent research careers.
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| Administrative Supplement for the NIBIB Research Education Programs for Residents and Clinical Fellows (Admin Supp Clilnical Trial Not Allowed) Apply for PA 18 680 Funding Number: PA 18 680 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Not Allowed) Apply for PA 18 682 Funding Number: PA 18 682 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics (R33 Clinical Trial Required) Apply for PAR 18 684 Funding Number: PAR 18 684 Agency: National Institutes of Health Category: Health Funding Amount: $1,515,000 |
| NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics (R61/R33 Clinical Trial Required) Apply for PAR 18 683 Funding Number: PAR 18 683 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Postdoctoral Mentored Career Development Award (K01 No Independent Clinical Trial Allowed) Apply for PAR 18 686 Funding Number: PAR 18 686 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Postdoctoral Mentored Career Development Award (K01 Clinical Trial Required) Apply for PAR 18 685 Funding Number: PAR 18 685 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition : HIV/AIDS-related Non-Human Primate Animal Research Facilities Restoration Program in the Aftermath of Hurricane Maria (C06 Clinical Trial Not Allowed) Apply for PAR 18 693 Funding Number: PAR 18 693 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| USAID/Kyrgyz Republic Tuberculosis (TB) Control Program Apply for RFI 72011519RFA00001 Funding Number: RFI 72011519RFA00001 Agency: Kazakhstan USAID-Almaty Category: Health Funding Amount: Case Dependent |
| Center without Walls for PET Ligand Development for Alzheimer's disease related dementias (ADRDs) (U19 Clinical Trial Optional) Apply for RFA NS 18 025 Funding Number: RFA NS 18 025 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Interdisciplinary Research Teams to Investigate Reciprocal Basic Behavioral and Social Linkages Between Sleep and Stress (R24 Clinical Trial Optional) Apply for PAR 18 694 Funding Number: PAR 18 694 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required) Apply for PAR 18 696 Funding Number: PAR 18 696 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed) Apply for PA 18 699 Funding Number: PA 18 699 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional) Apply for PAR 18 701 Funding Number: PAR 18 701 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Natural Product, Multi-Site, Clinical Trial, Data Coordinating Center (Collaborative U24 - Clinical Trial Required) Apply for PAR 18 697 Funding Number: PAR 18 697 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Stimulating T4 Implementation Research to Optimize Integration of Proven-effective Interventions for Heart, Lung, and Blood Diseases and Sleep Disorders into Practice (STIMULATE) (R01 Clinical Trial Not Allowed) Apply for RFA HL 19 014 Funding Number: RFA HL 19 014 Agency: National Institutes of Health Category: Health Funding Amount: $485,000 |
| Basic and Translational Oral Health Research Related to HIV/AIDS (R21 Clinical Trial Not Allowed) Apply for PA 18 695 Funding Number: PA 18 695 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32) (Clinical Trials Not Allowed) Apply for PA 18 700 Funding Number: PA 18 700 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Translational Research Program (TRP) on Therapy for Visual Disorders (R24 Clinical Trial Optional) Apply for PAR 18 707 Funding Number: PAR 18 707 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Selective Cell and Network Vulnerability in Aging and Alzheimers Disease (R01 - Clinical Trial Not Allowed) Apply for PAR 18 706 Funding Number: PAR 18 706 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allowed) Apply for RFA AI 18 002 Funding Number: RFA AI 18 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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