Opportunity Information: Apply for RFA DP 16 003

The Johnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic Diseases is a CDC funding opportunity (RFA DP 16 003) intended to strengthen the public health evidence base on osteoarthritis (OA), especially the hip and knee forms that drive a large share of arthritis-related disability. The opportunity is rooted in the recognition that arthritis affects roughly 52.5 million U.S. adults and represents the most common cause of disability nationally, yet it has not been studied at a level that matches its scale and impact. The announcement also highlights a particular gap in understanding OA among African American populations, where the burden is substantial and where differences in outcomes and contributing factors may not be fully captured by existing research.

The main goal of the cooperative agreement is to support a population-based, longitudinal study in Johnston County that follows people over time to produce more precise and useful estimates of how often hip and knee OA occurs (incidence), how widespread it is (prevalence), and how it changes or worsens over time (progression). In addition to tracking OA itself, the project is expected to refine estimates for related outcomes tied to OA, such as functional limitations and disability, which are central to why OA is such an important public health issue.

A second major focus is identifying and evaluating factors that influence OA outcomes. That includes both risk factors and protective factors, and it explicitly calls for looking at the role of other chronic conditions that commonly occur alongside OA. In practical terms, this means the study is positioned to examine how comorbidities may accelerate OA progression, worsen pain or mobility, complicate disability trajectories, or potentially interact with modifiable exposures and behaviors. By building that broader chronic disease context into the research, the project aligns OA research with real-world patient experiences, where OA rarely occurs in isolation.

A third core objective is to determine racial or ethnic differences in OA outcomes and to assess whether the impact of risk factors and comorbid conditions differs across groups. This emphasis reflects the concern that population averages can mask meaningful disparities and that prevention strategies, clinical management, and community interventions may need to be tailored when the underlying drivers or consequences of OA differ by race or ethnicity. The announcement frames this as a key public health knowledge gap rather than a purely clinical question, tying the work to broader efforts around disability prevention and health equity.

The opportunity is offered by the Centers for Disease Control and Prevention (CDC) under CFDA 93.283, categorized as a health-related discretionary grant, and it uses a cooperative agreement mechanism, which generally implies substantial involvement from the CDC in shaping or supporting the work compared to a standard grant. The funding details list an award ceiling of $1,500,000 with one expected award, reflecting a single-site, focused investment rather than a multi-award competition. The funding need and rationale are explicitly linked to national planning documents, including the 1999 National Arthritis Action Plan and the 2010 National Public Health Agenda for Osteoarthritis, and it is described as a priority area for the CDC Arthritis Program.

Eligibility is highly restricted: the only organization eligible to apply is the University of North Carolina at Chapel Hill. The opportunity was created on 2015-12-11 with an original closing date of 2016-02-10, indicating it was designed as a targeted continuation or support mechanism for an established, population-based OA cohort effort centered in Johnston County rather than an open call for proposals from multiple institutions.

  • The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Johnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic Diseases" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283.
  • This funding opportunity was created on 2015-12-11.
  • Applicants must submit their applications by 2016-02-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others.
Apply for RFA DP 16 003

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Frequently Asked Questions (FAQs)

What is this funding opportunity?

The Johnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic Diseases is a Centers for Disease Control and Prevention (CDC) funding opportunity (RFA DP 16 003). It is designed to strengthen the public health evidence base on osteoarthritis (OA), with a particular emphasis on hip and knee OA and their role in arthritis-related disability.

Which federal agency is offering the award?

The opportunity is offered by the Centers for Disease Control and Prevention (CDC).

What is the CFDA number for this program?

The CFDA number listed for this opportunity is 93.283.

What type of funding mechanism is being used?

This opportunity uses a cooperative agreement mechanism. Compared to a standard grant, a cooperative agreement generally indicates substantial CDC involvement in shaping, supporting, or collaborating on the funded work.

What is the main purpose of the cooperative agreement?

The main goal is to support a population-based, longitudinal study in Johnston County that follows people over time to produce more precise and useful estimates of hip and knee OA incidence (how often it occurs), prevalence (how widespread it is), and progression (how it changes or worsens over time).

Why does the announcement focus on hip and knee osteoarthritis?

The opportunity highlights hip and knee OA because these forms account for a large share of arthritis-related disability, making them especially important for understanding and preventing disability at the population level.

What other outcomes are expected to be studied besides osteoarthritis itself?

In addition to tracking OA, the project is expected to refine estimates for outcomes related to OA, including functional limitations and disability. These outcomes are central to the public health significance of OA.

What does "population-based, longitudinal study" mean in this context?

Based on the announcement, it refers to a study designed to represent a population in Johnston County and to follow participants over time, allowing the project to measure how OA appears, how common it is, and how it progresses.

Does the opportunity address factors that influence OA outcomes?

Yes. A major focus is identifying and evaluating factors that influence OA outcomes, including both risk factors and protective factors.

How do other chronic conditions fit into the project?

The announcement explicitly calls for examining the role of other chronic conditions that commonly occur alongside OA. This includes assessing how comorbidities may accelerate OA progression, worsen pain or mobility, complicate disability trajectories, or interact with modifiable exposures and behaviors.

Is health equity or disparities research part of the scope?

Yes. A core objective is to determine racial or ethnic differences in OA outcomes and assess whether the impact of risk factors and comorbid conditions differs across groups. The announcement frames this as a key public health knowledge gap tied to disability prevention and health equity.

Why is osteoarthritis framed as a major public health issue in this announcement?

The opportunity notes that arthritis affects roughly 52.5 million U.S. adults and is described as the most common cause of disability nationally. It also indicates that OA has not been studied at a level matching its scale and impact.

Does the opportunity highlight any specific evidence gaps related to African American populations?

Yes. The announcement highlights a gap in understanding OA among African American populations, noting a substantial burden and suggesting that differences in outcomes and contributing factors may not be fully captured by existing research.

How many awards are expected to be made?

The funding details indicate one expected award, suggesting a single-site, focused investment rather than a multi-award competition.

What is the maximum funding amount (award ceiling)?

The award ceiling listed is $1,500,000.

Who is eligible to apply?

Eligibility is highly restricted. The only organization eligible to apply is the University of North Carolina at Chapel Hill.

Is this an open competition for multiple institutions?

No. Based on the stated eligibility limitation and the single expected award, the opportunity appears targeted rather than open to multiple institutions.

Where is the study expected to take place?

The announcement centers the work in Johnston County through the Johnston County Osteoarthritis Project and describes a population-based cohort effort located there.

When was the opportunity created?

The opportunity was created on 2015-12-11.

What was the original closing date?

The original closing date listed is 2016-02-10.

How is this opportunity connected to national public health plans or priorities?

The funding rationale is linked to national planning documents, including the 1999 National Arthritis Action Plan and the 2010 National Public Health Agenda for Osteoarthritis. The announcement describes this work as a priority area for the CDC Arthritis Program.

What is the grant category?

The opportunity is categorized as a health-related discretionary grant.

What kinds of estimates is the project expected to improve?

The project is expected to produce more precise estimates of hip and knee OA incidence, prevalence, and progression, and to refine estimates for related functional limitations and disability outcomes.

What is the broader research framing of the project?

The announcement positions OA research within a broader chronic disease context, emphasizing that OA often occurs alongside other chronic conditions and that understanding comorbidities is important for reflecting real-world disability and health trajectories.

Does the opportunity emphasize disability prevention?

Yes. Disability is repeatedly emphasized as a central public health consequence of OA, and the focus on functional limitations, disability outcomes, and equity is tied to broader disability prevention and health equity goals.

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