Opportunity Information: Apply for RFA MH 22 125
The National Institutes of Health (NIH) grant opportunity "Enhanced Interpersonal Focused Strategies for Suicide Prevention Interventions (R34 Clinical Trial Required)" (Funding Opportunity Number RFA-MH-22-125; CFDA 93.242) supports early-stage, clinical trial-focused research aimed at improving suicide prevention by strengthening the interpersonal side of intervention. The core idea is that many existing suicide prevention approaches do a solid job with safety management planning and teaching intrapersonal coping skills (things a person can do on their own, such as emotion regulation or distress tolerance), but they often spend less time directly addressing interpersonal drivers of suicide risk, such as feeling disconnected, burdensome, or lacking meaningful social support. This program is designed to push the field toward interventions that more directly target social connection and perceived support in ways that align with established conceptual models of suicide risk, with the ultimate goal of reducing suicidal thoughts and behaviors and reinforcing life-affirming beliefs, intentions, and actions.
This is an R34 mechanism, which generally means the focus is on intervention development, refinement, and preliminary testing to establish feasibility, acceptability, and early signals of effectiveness before moving to larger, fully powered efficacy or effectiveness trials. The "Clinical Trial Required" designation signals that applicants are expected to include a clinical trial component rather than purely observational or basic research. Within that clinical trial framework, the opportunity emphasizes developing new interpersonal-focused strategies and/or integrating interpersonal strategies into existing evidence-based treatments. In practice, that could include adapting established therapies to better build or repair supportive relationships, improving engagement of family or peer supports, or creating structured components that increase belongingness and social connectedness, provided the approach is grounded in theory and designed to measurably affect suicide risk pathways.
The initiative is broad in who can apply, reflecting an interest in diverse settings and populations. Eligible applicants include state, county, and local governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized governments); public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly notes eligibility for a range of mission-driven and community-rooted organizations and institutions, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, the notice draws clear boundaries around foreign participation: non-domestic (non-U.S.) entities and non-U.S. components of U.S. organizations are not eligible to apply, although "foreign components" may be allowed as defined by the NIH Grants Policy Statement, which typically means certain project elements can occur abroad under specific NIH rules even when the applicant organization itself must be U.S.-based.
In terms of funding details provided, the opportunity is categorized as discretionary and uses a grant funding instrument within the health activity category. The posted award ceiling is $450,000, and the original closing date listed is 2022-02-18, with a creation date of 2021-10-18. Overall, the program is essentially a targeted push to move suicide prevention beyond individual-only coping and crisis planning by rigorously developing and testing interpersonal intervention strategies that can augment existing treatments or form the basis of new approaches, especially strategies that strengthen real and perceived social connection as a protective factor against suicide risk.Apply for RFA MH 22 125
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Enhanced Interpersonal Focused Strategies for Suicide Prevention Interventions (R34 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2021-10-18.
- Applicants must submit their applications by 2022-02-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Enhanced Interpersonal Focused Strategies for Suicide Prevention Interventions (R34 Clinical Trial Required)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-MH-22-125.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.242.
What is the main purpose of this grant?
This NIH opportunity supports early-stage, clinical trial-focused research to improve suicide prevention by strengthening the interpersonal side of intervention. The goal is to more directly target social connection and perceived support in ways that align with established conceptual models of suicide risk, ultimately reducing suicidal thoughts and behaviors and reinforcing life-affirming beliefs, intentions, and actions.
What gap in current suicide prevention approaches is this opportunity trying to address?
The opportunity is aimed at addressing a common imbalance in existing interventions: many approaches emphasize safety management planning and intrapersonal coping skills (skills a person can use independently, such as emotion regulation and distress tolerance) but spend less time directly addressing interpersonal drivers of suicide risk, such as feeling disconnected, feeling burdensome, or lacking meaningful social support.
What does "interpersonal-focused strategies" mean in this context?
In this context, interpersonal-focused strategies are intervention components designed to improve real and/or perceived social connection and support. These strategies aim to directly impact interpersonal pathways related to suicide risk, such as strengthening belongingness, improving supportive relationships, or increasing engagement of family or peer supports.
What kind of research mechanism is this (R34), and what does that imply?
This is an R34 mechanism, which generally focuses on intervention development, refinement, and preliminary testing. The intent is to establish feasibility, acceptability, and early signals of effectiveness before moving to larger, fully powered efficacy or effectiveness trials.
Is a clinical trial required under this opportunity?
Yes. The opportunity is explicitly labeled "Clinical Trial Required," meaning applications are expected to include a clinical trial component rather than being purely observational or basic research.
What types of projects does NIH appear to be encouraging?
Based on the description, NIH is encouraging projects that develop new interpersonal-focused strategies and/or integrate interpersonal strategies into existing evidence-based treatments. Examples mentioned include adapting established therapies to better build or repair supportive relationships, improving engagement of family or peer supports, and creating structured components that increase belongingness and social connectedness, as long as the approach is theory-grounded and designed to measurably affect suicide risk pathways.
Does this opportunity support creating entirely new interventions, or only adapting existing ones?
It supports both. The description highlights developing new interpersonal-focused strategies and also integrating interpersonal strategies into existing evidence-based treatments.
What outcomes or impacts is this program ultimately trying to achieve?
The stated ultimate goal is reducing suicidal thoughts and behaviors while reinforcing life-affirming beliefs, intentions, and actions, by more directly addressing interpersonal drivers and strengthening real and perceived social connection as a protective factor.
Who is eligible to apply?
The opportunity lists a broad range of eligible applicants, including state, county, and local governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized governments); public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses.
Are community-rooted and mission-driven organizations included in eligibility?
Yes. The announcement explicitly notes eligibility for a range of mission-driven and community-rooted organizations and institutions, including faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are minority-serving institutions and tribal colleges explicitly included?
Yes. The opportunity explicitly calls out several categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and federally recognized tribal governments and tribal organizations.
Can federal government agencies apply?
Yes. The eligibility list includes eligible federal government agencies.
Can for-profit entities apply?
Yes. The eligibility list includes for-profit organizations (other than small businesses) and also separately includes small businesses.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply under this opportunity.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The description states that non-U.S. components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all?
The description notes that "foreign components" may be allowed as defined by the NIH Grants Policy Statement. This typically means certain elements of a project may occur abroad under specific NIH rules, even when the applicant organization must be U.S.-based.
What is the maximum award amount listed for this opportunity?
The posted award ceiling is $450,000.
What type of funding instrument is used?
The opportunity uses a grant funding instrument.
How is this opportunity categorized?
It is categorized as discretionary and falls under the health activity category.
What are the key dates provided?
The creation date listed is 2021-10-18, and the original closing date listed is 2022-02-18.
What is the central theme distinguishing this initiative from more individually focused approaches?
The central theme is moving beyond individual-only coping and crisis planning by rigorously developing and testing interpersonal intervention strategies. The emphasis is on strategies that strengthen real and perceived social connection and support, consistent with conceptual models of suicide risk.
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