Opportunity Information: Apply for HT942526TERPTRA

The FY26 Toxic Exposures Research Program (TERP) Translational Research Award (TRA) is a Department of Defense grant opportunity designed to push military-related toxic exposure research beyond early discovery and closer to real-world clinical use. The core goal is to speed up the transition of promising findings into clinical applications that can directly improve health outcomes, such as health care products, medical interventions, new or improved technologies, and clinical practice guidelines. In other words, the program is looking for projects that do more than describe a problem; it wants research that actively bridges the gap between what is learned in the lab and what can be implemented in clinics and health systems supporting service members, veterans, and other affected populations.

A key expectation is that proposed work clearly qualifies as translational research, defined here as an integration of basic science and clinical observations. Applicants are expected to show a two-way flow of information between basic and clinical domains, meaning the proposal should demonstrate how clinical observations shape laboratory or mechanistic work and/or how basic science discoveries are being refined and positioned for clinical testing, validation, or adoption. The program also notes that New Approach Methodologies may be used, signaling openness to modern methods that can strengthen translation, accelerate validation, or improve confidence in findings that are intended to influence clinical decisions.

This award has a distinctive collaboration structure intended to strengthen interdisciplinary teams. The FY26 TRA includes a Partnering Principal Investigator Option (PPIO). Under this model, one Principal Investigator is designated as the initiating PI, and a second PI can be named as a Partnering PI. If the application is selected for funding, each PI receives a separate award while working within the same partnered project. The purpose is to encourage meaningful, productive collaborations, particularly partnerships that combine complementary expertise, such as clinicians working closely with research scientists. The collaboration is not meant to be superficial; the announcement emphasizes that the partnership should substantially advance the work beyond what either PI could accomplish independently, with the practical aim of moving the research more efficiently toward clinical application.

Administratively, this opportunity is listed as a discretionary grant in the Science and Technology and other Research and Development category and is associated with CFDA number 12.420. The funding opportunity number is HT942526TERPTRA, and the sponsoring agency is the Defense Health Agency Contracting Activity (DHACA). Eligibility is described as unrestricted, indicating there are no special applicant-type limits stated in the provided notice. The original closing date is November 19, 2026, and the program anticipates making about four awards. The public notice was created on May 21, 2026. More information is referenced in the program press announcement at https://cdmrp.health.mil/pubs/press/2026/terppreann.

  • The Defense Health Agency Contracting Activity - DHACA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Toxic Exposures Translational Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on 2026-05-21.
  • Applicants must submit their applications by 2026-11-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: Unrestricted.
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FY26 Toxic Exposures Research Program (TERP) Translational Research Award (TRA) - FAQs

What is the FY26 TERP Translational Research Award (TRA)?

The FY26 Toxic Exposures Research Program (TERP) Translational Research Award (TRA) is a Department of Defense grant opportunity focused on moving military-related toxic exposure research beyond early discovery and closer to real-world clinical use.

What is the main goal of this award?

The core goal is to speed the transition of promising research findings into clinical applications that can directly improve health outcomes. Examples described include health care products, medical interventions, new or improved technologies, and clinical practice guidelines.

What kinds of outcomes is the program trying to support?

Based on the notice, the program is looking for projects that support translation into practical clinical outputs such as products, interventions, technologies, or guidelines that can be implemented in clinics and health systems.

Does this program fund basic discovery research?

The emphasis is on projects that go beyond describing a problem or early discovery alone. The opportunity is designed to bridge the gap between laboratory findings and what can be implemented in clinical settings, with the intent of moving research closer to clinical testing, validation, or adoption.

What does "translational research" mean for this opportunity?

For this award, translational research is defined as an integration of basic science and clinical observations, with a two-way flow of information between the basic and clinical domains. This means proposals should show how clinical observations inform laboratory or mechanistic work and/or how basic discoveries are being refined and positioned for clinical testing, validation, or adoption.

What is meant by a "two-way flow" between clinical and basic research?

The notice indicates applicants should demonstrate that clinical observations shape the basic science work and/or that basic science discoveries are actively being prepared for clinical evaluation or use. The expectation is that basic and clinical components inform each other rather than operating as separate, one-directional efforts.

Are modern or alternative methods allowed (for example, New Approach Methodologies)?

Yes. The opportunity notes that New Approach Methodologies may be used, which signals openness to modern methods that can strengthen translation, accelerate validation, or improve confidence in findings intended to influence clinical decisions.

Who is this research intended to benefit?

The opportunity is oriented toward clinical implementation in settings supporting service members, veterans, and other affected populations impacted by military-related toxic exposures.

What is the Partnering Principal Investigator Option (PPIO)?

The FY26 TRA includes a Partnering Principal Investigator Option (PPIO) designed to strengthen interdisciplinary teamwork. Under this option, one Principal Investigator is designated as the initiating PI, and a second PI may be named as the Partnering PI.

How does funding work under the Partnering PI model?

If the application is selected for funding, each PI receives a separate award while working within the same partnered project.

Why does the program include a Partnering PI option?

The stated purpose is to encourage meaningful, productive collaborations that combine complementary expertise, such as clinicians working closely with research scientists, to move the research more efficiently toward clinical application.

What level of collaboration is expected between the initiating PI and Partnering PI?

The partnership is not intended to be superficial. The notice emphasizes that the collaboration should substantially advance the work beyond what either PI could accomplish independently, with a practical focus on accelerating progress toward clinical use.

Is this a discretionary grant?

Yes. The opportunity is listed as a discretionary grant in the Science and Technology and other Research and Development category.

What is the CFDA number associated with this opportunity?

The notice associates this opportunity with CFDA number 12.420.

What is the funding opportunity number?

The funding opportunity number listed is HT942526TERPTRA.

Which agency is sponsoring this grant opportunity?

The sponsoring agency is the Defense Health Agency Contracting Activity (DHACA).

Who is eligible to apply?

Eligibility is described as unrestricted in the provided notice, meaning there are no special applicant-type limits stated there.

How many awards does the program expect to make?

The program anticipates making about four awards.

What is the closing date for applications?

The original closing date listed is November 19, 2026.

When was the public notice created?

The public notice was created on May 21, 2026.

Where can applicants find the referenced program press announcement?

More information is referenced in the program press announcement available at https://cdmrp.health.mil/pubs/press/2026/terppreann.

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