Opportunity Information: Apply for W81XWH 21 MSRP CTA
The Department of Defense (DoD), through the U.S. Army Medical Research Acquisition Activity (USAMRAA), offered the Multiple Sclerosis Research Program (MSRP) Clinical Trial Award (CTA) to speed up the launch of clinical trials that could meaningfully improve how multiple sclerosis (MS) is treated or managed. The main purpose of this opportunity is practical and impact-focused: moving credible, well-justified trial concepts into real-world testing quickly, with the expectation that the results could change clinical decision-making, patient outcomes, or the direction of MS care.
This award is designed specifically for clinical trials rather than basic or preclinical research. Projects can test a broad range of interventions and strategies, including new or repurposed pharmacologic agents (such as drugs or biologics), medical devices, clinical guidance approaches, and newer technologies or emerging therapeutic methods. In other words, the program is open to different kinds of trial-ready ideas, as long as the proposal centers on a clinical study intended to evaluate safety, feasibility, or early efficacy in people (or otherwise in a relevant patient population consistent with the proposed trial phase).
The scope of supported trials is intentionally flexible, covering early and mid-stage clinical development. On the smaller end, applicants can propose proof-of-concept efforts such as pilot studies, first-in-human trials, or phase 0 trials, particularly when the goal is to demonstrate feasibility, establish initial safety signals, or generate data that will inform the design of a more definitive study. On the larger end, the award can support phase 1 and phase 2 trials that more directly evaluate safety and/or efficacy in an MS patient population, helping determine whether an intervention is promising enough to justify later-stage testing or broader adoption.
From an administrative and funding standpoint, the opportunity was listed as a discretionary funding program under the category of Science and Technology and other Research and Development (CFDA 12.420). Awards could be made as either grants or cooperative agreements, meaning the level of government involvement could vary depending on the specific award mechanism and project needs. Eligibility was described as unrestricted (open to any type of entity), subject to any additional eligibility details that may have been included in the full announcement text. The funding opportunity number was W81XWH-21-MSRP-CTA, and the posting indicates an expected three awards. The listing shows an award ceiling of 0, which typically signals that a specific cap was not provided in the summary fields and would need to be confirmed in the full solicitation or program guidance. The opportunity was created on May 10, 2021, with an original closing date of October 1, 2021.
Overall, this grant opportunity targets teams that are ready to execute a well-planned MS clinical trial on an accelerated timeline, with a clear clinical rationale and a realistic path to generating results that could influence MS treatment or management in the near term.Apply for W81XWH 21 MSRP CTA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Multiple Sclerosis Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 10, 2021.
- Applicants must submit their applications by Oct 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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| Funding Opportunity |
|---|
| DOD Multiple Sclerosis Exploration - Hypothesis Development Award Apply for W81XWH 21 MSRP EHDA Funding Number: W81XWH 21 MSRP EHDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Multiple Sclerosis Investigator-Initiated Research Award Apply for W81XWH 21 MSRP IIRA Funding Number: W81XWH 21 MSRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| FY21 DEFENSE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (DEPSCoR) – CAPACITY BUILDING (CB) Apply for FOA AFRL AFOSR 2021 0008 Funding Number: FOA AFRL AFOSR 2021 0008 Agency: Department of Defense, Air Force Office of Scientific Research Category: Science and Technology and other Research and Development Funding Amount: $1,000,000 |
| DOD Multiple Sclerosis Early Investigator Research Award Apply for W81XWH 21 MSRP EIRA Funding Number: W81XWH 21 MSRP EIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Thermophotovoltaic (TPV) Cell Array Assembly Research Apply for W911NF 17 S 0003 SPECIALNOTICE TPV CELL Funding Number: W911NF 17 S 0003 SPECIALNOTICE TPV CELL Agency: Department of Defense, Dept of the Army -- Materiel Command Category: Science and Technology and other Research and Development Funding Amount: $350,000 |
| DEPARTMENT OF DEFENSE (DoD) FY 2022 Research and Education Program for Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI) Equipment/Instrumentation Apply for W911NF 21 S 0011 Funding Number: W911NF 21 S 0011 Agency: Department of Defense, Dept of the Army -- Materiel Command Category: Science and Technology and other Research and Development Funding Amount: $600,000 |
| Disrupting Operations of Illicit Supply Networks Apply for 21 582 Funding Number: 21 582 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Vision, Clinical Trial Award Apply for W81XWH 21 VRP CTA Funding Number: W81XWH 21 VRP CTA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Vision, Translational Research Award Apply for W81XWH 21 VRP TRA Funding Number: W81XWH 21 VRP TRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Vision, Investigator- Initiated Research Award Apply for W81XWH 21 VRP IIRA Funding Number: W81XWH 21 VRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Vision, Focused Translational Team Science Award Apply for W81XWH 21 VRP FTTSA Funding Number: W81XWH 21 VRP FTTSA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Scleroderma, Translational Research Partnership Award Apply for W81XWH 21 SRP TRPA Funding Number: W81XWH 21 SRP TRPA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Scleroderma, Idea Development Award Apply for W81XWH 21 SRP IDA Funding Number: W81XWH 21 SRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Pancreatic Cancer, Idea Development Award Apply for W81XWH 21 PCARP IDA Funding Number: W81XWH 21 PCARP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Pancreatic Cancer, Translational Research Partnership Award Apply for W81XWH 21 PCARP TRPA Funding Number: W81XWH 21 PCARP TRPA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Rare Cancers Concept Award Apply for W81XWH 21 RCRP CA Funding Number: W81XWH 21 RCRP CA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Rare Cancers Idea Development Award Apply for W81XWH 21 RCRP IDA Funding Number: W81XWH 21 RCRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Rare Cancers Resource and Community Development Award Apply for W81XWH 21 RCRP RCDA Funding Number: W81XWH 21 RCRP RCDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| CISA Cyber Security Awareness Campaign Apply for IS CSA 21 002 Funding Number: IS CSA 21 002 Agency: Department of Homeland Security, Office of Procurement Operations - Grants Division Category: Science and Technology and other Research and Development Funding Amount: $549,996 |
| CISA Cyber Security Awareness Campaign Apply for DHS 21 CISA 128 CSA001 Funding Number: DHS 21 CISA 128 CSA001 Agency: Department of Homeland Security, Office of Procurement Operations - Grants Division Category: Science and Technology and other Research and Development Funding Amount: $549,996 |
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